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Chemical Inhibition of Bacterial Ribosome Biogenesis Shows Efficacy in a Worm Infection Model

The development of antibacterial compounds that perturb novel processes is an imperative in the challenge presented by widespread antibiotic resistance. While many antibiotics target the ribosome, molecules that inhibit ribosome assembly have yet to be used in this manner. Here we show that a novel...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Stokes, Jonathan M., Selin, Carrie, Cardona, Silvia T., Brown, Eric D.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394774/
https://ncbi.nlm.nih.gov/pubmed/25712357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04690-14
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