Cyclophilin and NS5A Inhibitors, but Not Other Anti-Hepatitis C Virus (HCV) Agents, Preclude HCV-Mediated Formation of Double-Membrane-Vesicle Viral Factories

Although the mechanisms of action (MoA) of nonstructural protein 3 inhibitors (NS3i) and NS5B inhibitors (NS5Bi) are well understood, the MoA of cyclophilin inhibitors (CypI) and NS5A inhibitors (NS5Ai) are not fully defined. In this study, we examined whether CypI and NS5Ai interfere with hepatitis...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Chatterji, Udayan, Bobardt, Michael, Tai, Andrew, Wood, Malcolm, Gallay, Philippe A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394764/
https://ncbi.nlm.nih.gov/pubmed/25666154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04958-14
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