G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

Dephosphorylation of eukaryotic translation initiation factor 2a (eIF2a) restores protein synthesis at the waning of stress responses and requires a PP1 catalytic subunit and a regulatory subunit, PPP1R15A/GADD34 or PPP1R15B/CReP. Surprisingly, PPP1R15-PP1 binary complexes reconstituted in vitro lac...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Chen, Ruming, Rato, Cláudia, Yan, Yahui, Crespillo-Casado, Ana, Clarke, Hanna J, Harding, Heather P, Marciniak, Stefan J, Read, Randy J, Ron, David
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2015
Matèries:
Biochemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394352/
https://ncbi.nlm.nih.gov/pubmed/25774600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04871
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