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G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases
Dephosphorylation of eukaryotic translation initiation factor 2a (eIF2a) restores protein synthesis at the waning of stress responses and requires a PP1 catalytic subunit and a regulatory subunit, PPP1R15A/GADD34 or PPP1R15B/CReP. Surprisingly, PPP1R15-PP1 binary complexes reconstituted in vitro lac...
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| Vydáno v: | eLife |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
eLife Sciences Publications, Ltd
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394352/ https://ncbi.nlm.nih.gov/pubmed/25774600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04871 |
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