Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation

Four stress-sensing kinases phosphorylate the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α) to activate the integrated stress response (ISR). In animals, the ISR is antagonised by selective eIF2α phosphatases comprising a catalytic protein phosphatase 1 (PP1) subunit in complex...

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Foilsithe in:eLife
Main Authors: Chambers, Joseph E, Dalton, Lucy E, Clarke, Hanna J, Malzer, Elke, Dominicus, Caia S, Patel, Vruti, Moorhead, Greg, Ron, David, Marciniak, Stefan J
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2015
Ábhair:
Biochemistry
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394351/
https://ncbi.nlm.nih.gov/pubmed/25774599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04872
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