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Phosphorylation of ORF1p is required for L1 retrotransposition

Although members of the L1 (LINE-1) clade of non-LTR retrotransposons can be deleterious, the L1 clade has remained active in most mammals for ∼100 million years and generated almost 40% of the human genome. The details of L1–host interaction are largely unknown, however. Here we report that L1 acti...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cook, Pamela R., Jones, Charles E., Furano, Anthony V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394301/
https://ncbi.nlm.nih.gov/pubmed/25831499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416869112
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