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Cryptic genetic variation enhances primate L1 retrotransposon survival by enlarging the functional coiled coil sequence space of ORF1p

Accounting for continual evolution of deleterious L1 retrotransposon families, which can contain hundreds to thousands of members remains a major issue in mammalian biology. L1 activity generated upwards of 40% of some mammalian genomes, including humans where they remain active, causing genetic def...

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Vydáno v:PLoS Genet
Hlavní autoři: Furano, Anthony V., Jones, Charlie E., Periwal, Vipul, Callahan, Kathryn E., Walser, Jean-Claude, Cook, Pamela R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449397/
https://ncbi.nlm.nih.gov/pubmed/32797042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008991
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