Biochemical characterization of a Naegleria TET-like oxygenase and its application in single molecule sequencing of 5-methylcytosine

Modified DNA bases in mammalian genomes, such as 5-methylcytosine ((5m)C) and its oxidized forms, are implicated in important epigenetic regulation processes. In human or mouse, successive enzymatic conversion of (5m)C to its oxidized forms is carried out by the ten-eleven translocation (TET) protei...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Pais, June E., Dai, Nan, Tamanaha, Esta, Vaisvila, Romualdas, Fomenkov, Alexey I., Bitinaite, Jurate, Sun, Zhiyi, Guan, Shengxi, Corrêa, Ivan R., Noren, Christopher J., Cheng, Xiaodong, Roberts, Richard J., Zheng, Yu, Saleh, Lana
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394277/
https://ncbi.nlm.nih.gov/pubmed/25831492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417939112
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