Biochemical characterization of a Naegleria TET-like oxygenase and its application in single molecule sequencing of 5-methylcytosine

Modified DNA bases in mammalian genomes, such as 5-methylcytosine ((5m)C) and its oxidized forms, are implicated in important epigenetic regulation processes. In human or mouse, successive enzymatic conversion of (5m)C to its oxidized forms is carried out by the ten-eleven translocation (TET) protei...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Pais, June E., Dai, Nan, Tamanaha, Esta, Vaisvila, Romualdas, Fomenkov, Alexey I., Bitinaite, Jurate, Sun, Zhiyi, Guan, Shengxi, Corrêa, Ivan R., Noren, Christopher J., Cheng, Xiaodong, Roberts, Richard J., Zheng, Yu, Saleh, Lana
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394277/
https://ncbi.nlm.nih.gov/pubmed/25831492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417939112
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