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Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping

Despite considerable progress in uncovering the molecular details of protein aggregation in vitro, the cause and mechanism of protein-aggregation disease remain poorly understood. One reason is that the amount of pathological aggregates in neural tissue is exceedingly low, precluding examination by...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bergh, Johan, Zetterström, Per, Andersen, Peter M., Brännström, Thomas, Graffmo, Karin S., Jonsson, P. Andreas, Lang, Lisa, Danielsson, Jens, Oliveberg, Mikael, Marklund, Stefan L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394267/
https://ncbi.nlm.nih.gov/pubmed/25802384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419228112
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