Cytotoxicity of Superoxide Dismutase 1 in Cultured Cells Is Linked to Zn(2+) Chelation

Neurodegeneration in protein-misfolding disease is generally assigned to toxic function of small, soluble protein aggregates. Largely, these assignments are based on observations of cultured neural cells where the suspect protein material is titrated directly into the growth medium. In the present s...

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Bibliographic Details
Main Authors: Johansson, Ann-Sofi, Vestling, Monika, Zetterström, Per, Lang, Lisa, Leinartaitė, Lina, Karlström, Mikael, Danielsson, Jens, Marklund, Stefan L., Oliveberg, Mikael
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338499/
https://ncbi.nlm.nih.gov/pubmed/22558346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036104
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