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Fibrillation precursor of superoxide dismutase 1 revealed by gradual tuning of the protein-folding equilibrium
Although superoxide dismutase 1 (SOD1) stands out as a relatively soluble protein in vitro, it can be made to fibrillate by mechanical agitation. The mechanism of this fibrillation process is yet poorly understood, but attains considerable interest due to SOD1’s involvement in the neurodegenerative...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3497812/ https://ncbi.nlm.nih.gov/pubmed/22797895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201795109 |
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