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The Impact of Covariate Adjustment at Randomization and Analysis For Binary Outcomes: Understanding Differences Between Superiority and Non-Inferiority Trials

The question of when to adjust for important prognostic covariates often arises in the design of clinical trials, and there remain various opinions on whether to adjust during both randomization and analysis, at randomization alone, or at analysis alone. Furthermore, little is known about the impact...

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Detalhes bibliográficos
Publicado no:Stat Med
Main Authors: Nicholas, Katherine, Yeatts, Sharon D, Zhao, Wenle, Ciolino, Jody, Borg, Keith, Durkalski, Valerie
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393769/
https://ncbi.nlm.nih.gov/pubmed/25641057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6447
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