Renal Tubule Angiotensin II Type 1 Receptor–Associated Protein Promotes Natriuresis and Inhibits Salt‐Sensitive Blood Pressure Elevation

BACKGROUND: Angiotensin II type 1 receptor (AT1R)–associated protein (ATRAP; Agtrap gene) promotes AT1R internalization along with suppression of pathological AT1R activation. In this study, we examined whether enhancement of ATRAP in the renal distal tubules affects sodium handling and blood pressu...

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Vydáno v:J Am Heart Assoc
Hlavní autoři: Wakui, Hiromichi, Uneda, Kazushi, Tamura, Kouichi, Ohsawa, Masato, Azushima, Kengo, Kobayashi, Ryu, Ohki, Kohji, Dejima, Toru, Kanaoka, Tomohiko, Tsurumi‐Ikeya, Yuko, Matsuda, Miyuki, Haruhara, Kotaro, Nishiyama, Akira, Yabana, Machiko, Fujikawa, Tetsuya, Yamashita, Akio, Umemura, Satoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392439/
https://ncbi.nlm.nih.gov/pubmed/25792129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001594
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