Renal Tubule Angiotensin II Type 1 Receptor–Associated Protein Promotes Natriuresis and Inhibits Salt‐Sensitive Blood Pressure Elevation

BACKGROUND: Angiotensin II type 1 receptor (AT1R)–associated protein (ATRAP; Agtrap gene) promotes AT1R internalization along with suppression of pathological AT1R activation. In this study, we examined whether enhancement of ATRAP in the renal distal tubules affects sodium handling and blood pressu...

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Dades bibliogràfiques
Publicat a:J Am Heart Assoc
Autors principals: Wakui, Hiromichi, Uneda, Kazushi, Tamura, Kouichi, Ohsawa, Masato, Azushima, Kengo, Kobayashi, Ryu, Ohki, Kohji, Dejima, Toru, Kanaoka, Tomohiko, Tsurumi‐Ikeya, Yuko, Matsuda, Miyuki, Haruhara, Kotaro, Nishiyama, Akira, Yabana, Machiko, Fujikawa, Tetsuya, Yamashita, Akio, Umemura, Satoshi
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2015
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392439/
https://ncbi.nlm.nih.gov/pubmed/25792129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001594
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