Renal Tubule Angiotensin II Type 1 Receptor–Associated Protein Promotes Natriuresis and Inhibits Salt‐Sensitive Blood Pressure Elevation

BACKGROUND: Angiotensin II type 1 receptor (AT1R)–associated protein (ATRAP; Agtrap gene) promotes AT1R internalization along with suppression of pathological AT1R activation. In this study, we examined whether enhancement of ATRAP in the renal distal tubules affects sodium handling and blood pressu...

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Detalles Bibliográficos
Publicado en:J Am Heart Assoc
Main Authors: Wakui, Hiromichi, Uneda, Kazushi, Tamura, Kouichi, Ohsawa, Masato, Azushima, Kengo, Kobayashi, Ryu, Ohki, Kohji, Dejima, Toru, Kanaoka, Tomohiko, Tsurumi‐Ikeya, Yuko, Matsuda, Miyuki, Haruhara, Kotaro, Nishiyama, Akira, Yabana, Machiko, Fujikawa, Tetsuya, Yamashita, Akio, Umemura, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2015
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392439/
https://ncbi.nlm.nih.gov/pubmed/25792129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001594
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