Myeloperoxidase-dependent Lipid Peroxidation Promotes the Oxidative Modification of Cytosolic Proteins in Phagocytic Neutrophils

Phagocytic neutrophils generate reactive oxygen species to kill microbes. Oxidant generation occurs within an intracellular phagosome, but diffusible species can react with the neutrophil and surrounding tissue. To investigate the extent of oxidative modification, we assessed the carbonylation of cy...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Wilkie-Grantham, Rachel P., Magon, Nicholas J., Harwood, D. Tim, Kettle, Anthony J., Vissers, Margreet C., Winterbourn, Christine C., Hampton, Mark B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392286/
https://ncbi.nlm.nih.gov/pubmed/25697357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.613422
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