Myeloperoxidase-dependent Lipid Peroxidation Promotes the Oxidative Modification of Cytosolic Proteins in Phagocytic Neutrophils

Phagocytic neutrophils generate reactive oxygen species to kill microbes. Oxidant generation occurs within an intracellular phagosome, but diffusible species can react with the neutrophil and surrounding tissue. To investigate the extent of oxidative modification, we assessed the carbonylation of cy...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wilkie-Grantham, Rachel P., Magon, Nicholas J., Harwood, D. Tim, Kettle, Anthony J., Vissers, Margreet C., Winterbourn, Christine C., Hampton, Mark B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392286/
https://ncbi.nlm.nih.gov/pubmed/25697357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.613422
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