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Rescue of Na(+) Affinity in Aspartate 928 Mutants of Na(+),K(+)-ATPase by Secondary Mutation of Glutamate 314

The Na(+),K(+)-ATPase binds Na(+) at three transport sites denoted I, II, and III, of which site III is Na(+)-specific and suggested to be the first occupied in the cooperative binding process activating phosphorylation from ATP. Here we demonstrate that the asparagine substitution of the aspartate...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Holm, Rikke, Einholm, Anja P., Andersen, Jens P., Vilsen, Bente
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392278/
https://ncbi.nlm.nih.gov/pubmed/25713066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625509
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