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Arginine substitution of a cysteine in transmembrane helix M8 converts Na(+),K(+)-ATPase to an electroneutral pump similar to H(+),K(+)-ATPase

Na(+),K(+)-ATPase and H(+),K(+)-ATPase are electrogenic and nonelectrogenic ion pumps, respectively. The underlying structural basis for this difference has not been established, and it has not been revealed how the H(+),K(+)-ATPase avoids binding of Na(+) at the site corresponding to the Na(+)-spec...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Holm, Rikke, Khandelwal, Jaanki, Einholm, Anja P., Andersen, Jens P., Artigas, Pablo, Vilsen, Bente
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240710/
https://ncbi.nlm.nih.gov/pubmed/28028214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617951114
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