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Arginine substitution of a cysteine in transmembrane helix M8 converts Na(+),K(+)-ATPase to an electroneutral pump similar to H(+),K(+)-ATPase
Na(+),K(+)-ATPase and H(+),K(+)-ATPase are electrogenic and nonelectrogenic ion pumps, respectively. The underlying structural basis for this difference has not been established, and it has not been revealed how the H(+),K(+)-ATPase avoids binding of Na(+) at the site corresponding to the Na(+)-spec...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5240710/ https://ncbi.nlm.nih.gov/pubmed/28028214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617951114 |
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