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The Rapid-onset Dystonia Parkinsonism Mutation D923N of the Na(+),K(+)-ATPase α3 Isoform Disrupts Na(+) Interaction at the Third Na(+) Site
Rapid-onset dystonia parkinsonism (RDP), a rare neurological disorder, is caused by mutation of the neuron-specific α3-isoform of Na(+),K(+)-ATPase. Here, we present the functional consequences of RDP mutation D923N. Relative to the wild type, the mutant exhibits a remarkable ∼200-fold reduction of...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924038/ https://ncbi.nlm.nih.gov/pubmed/20576601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123976 |
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