Small Peptide Inhibitor of JNK3 Protects Dopaminergic Neurons from MPTP Induced Injury via Inhibiting the ASK1-JNK3 Signaling Pathway

INTRODUCTION AND AIMS: The ASK1-JNK3 signaling pathway plays a pivotal role in the pathogenesis of Parkinson's disease (PD). The specific binding of β-arrestin2 to JNK3 is essential for activation of the ASK1-JNK3 cascade, representing a potential therapeutic target for preventing dopaminergic...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Pan, Jing, Li, Hui, Zhang, Bei, Xiong, Ran, Zhang, Yu, Kang, Wen-Yan, Chen, Wei, Zhao, Zong-Bo, Chen, Sheng-Di
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391862/
https://ncbi.nlm.nih.gov/pubmed/25856433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119204
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