Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disorder with progressive loss of dopaminergic (DA) neurons. Systemic inflammation is shown to initiate and exacerbate DA neuronal degeneration in the substantia nigra. The infiltration and transformation of immune cells from the peripheral...

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發表在:J Neuroinflammation
Main Authors: Qiao, Chen, Zhang, Qian, Jiang, Qingling, Zhang, Ting, Chen, Miaomiao, Fan, Yi, Ding, Jianhua, Lu, Ming, Hu, Gang
格式: Artigo
語言:Inglês
出版: BioMed Central 2018
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029067/
https://ncbi.nlm.nih.gov/pubmed/29966531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1236-z
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