Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disorder with progressive loss of dopaminergic (DA) neurons. Systemic inflammation is shown to initiate and exacerbate DA neuronal degeneration in the substantia nigra. The infiltration and transformation of immune cells from the peripheral...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Qiao, Chen, Zhang, Qian, Jiang, Qingling, Zhang, Ting, Chen, Miaomiao, Fan, Yi, Ding, Jianhua, Lu, Ming, Hu, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029067/
https://ncbi.nlm.nih.gov/pubmed/29966531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1236-z
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