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Preclinical Evaluation of a Novel SIRT1 Modulator SRT1720 in Multiple Myeloma Cells

SIRT1 belongs to the silent information regulator 2 (Sir2) protein family of enzymes and functions as a NAD(+)-dependent class III histone deacetylase. Here, we examined the anti-multiple myeloma (MM) activity of a novel oral agent, SRT1720, which targets SIRT1. Treatment of MM cells with SRT1720 in...

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Bibliografiske detaljer
Udgivet i:Br J Haematol
Main Authors: Chauhan, Dharminder, Bandi, Madhavi, Singh, Ajita V., Ray, Arghya, Raje, Noopur, Richardson, Paul, Anderson, Kenneth C.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391196/
https://ncbi.nlm.nih.gov/pubmed/21950728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2011.08888.x
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