SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

Sirtuins catalyze NAD(+)-dependent protein deacetylation and are critical regulators of transcription, apoptosis, metabolism, and aging. There are seven human sirtuins (SIRT1–7), and SIRT1 has been implicated as a key mediator of the pathways downstream of calorie restriction that have been shown to...

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Bibliografiske detaljer
Main Authors: Pacholec, Michelle, Bleasdale, John E., Chrunyk, Boris, Cunningham, David, Flynn, Declan, Garofalo, Robert S., Griffith, David, Griffor, Matt, Loulakis, Pat, Pabst, Brandon, Qiu, Xiayang, Stockman, Brian, Thanabal, Venkataraman, Varghese, Alison, Ward, Jessica, Withka, Jane, Ahn, Kay
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832984/
https://ncbi.nlm.nih.gov/pubmed/20061378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.088682
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