SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

Sirtuins catalyze NAD(+)-dependent protein deacetylation and are critical regulators of transcription, apoptosis, metabolism, and aging. There are seven human sirtuins (SIRT1–7), and SIRT1 has been implicated as a key mediator of the pathways downstream of calorie restriction that have been shown to...

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Detalhes bibliográficos
Main Authors: Pacholec, Michelle, Bleasdale, John E., Chrunyk, Boris, Cunningham, David, Flynn, Declan, Garofalo, Robert S., Griffith, David, Griffor, Matt, Loulakis, Pat, Pabst, Brandon, Qiu, Xiayang, Stockman, Brian, Thanabal, Venkataraman, Varghese, Alison, Ward, Jessica, Withka, Jane, Ahn, Kay
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832984/
https://ncbi.nlm.nih.gov/pubmed/20061378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.088682
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