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APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice
BACKGROUND: Alzheimer’s disease (AD) causes progressive loss of memory and cognition, exacerbated by APOE4, the greatest genetic risk factor for AD. One proposed mechanism for apolipoprotein E (apoE) effects on cognition is via NMDAR-dependent signaling. APOE genotype-specific effects on this pathwa...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Mol Neurodegener |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BioMed Central
2015
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4391134/ https://ncbi.nlm.nih.gov/pubmed/25871877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0002-2 |
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