APOE‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

Chronic glial activation and neuroinflammation induced by the amyloid‐β peptide (Aβ) contribute to Alzheimer's disease (AD) pathology. APOE4 is the greatest AD‐genetic risk factor; increasing risk up to 12‐fold compared to APOE3, with APOE4‐specific neuroinflammation an important component of t...

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Bibliografski detalji
Izdano u:J Neurochem
Glavni autori: Tai, Leon M., Ghura, Shivesh, Koster, Kevin P., Liakaite, Vaiva, Maienschein‐Cline, Mark, Kanabar, Pinal, Collins, Nicole, Ben‐Aissa, Manel, Lei, Arden Zhengdeng, Bahroos, Neil, Green, Stefan J., Hendrickson, Bill, Van Eldik, Linda J., LaDu, Mary Jo
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2015
Teme:
Review
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400246/
https://ncbi.nlm.nih.gov/pubmed/25689586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13072
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