Nitric oxide regulates gene expression in cancers by controlling histone posttranslational modifications

Altered nitric oxide (•NO) metabolism underlies cancer pathology, but mechanisms explaining many •NO-associated phenotypes remain unclear. We have found that cellular exposure to •NO changes histone posttranslational modifications (PTMs) by directly inhibiting the catalytic activity of JmjC-domain c...

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Udgivet i:Cancer Res
Main Authors: Vasudevan, Divya, Hickok, Jason R., Bovee, Rhea C., Pham, Vy, Mantell, Lin L., Bahroos, Neil, Kanabar, Pinal, Cao, Xing-Jun, Maienschein-Cline, Mark, Garcia, Benjamin A., Thomas, Douglas D.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681644/
https://ncbi.nlm.nih.gov/pubmed/26542213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1582
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