Allosteric Inhibitors Have Distinct Effects, but Also Common Modes of Action, in the HCV Polymerase

The RNA-dependent RNA polymerase from the Hepatitis C Virus (gene product NS5B) is a validated drug target because of its critical role in genome replication. There are at least four distinct allosteric sites on the polymerase to which several small molecule inhibitors bind. In addition, numerous cr...

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Bibliographic Details
Published in:Biophys J
Main Authors: Davis, Brittny C., Brown, Jodian A., Thorpe, Ian F.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2015
Subjects:
Proteins and Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4390812/
https://ncbi.nlm.nih.gov/pubmed/25863069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.03.005
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