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Thumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase
Hepatitis C virus (HCV) has infected almost 200 million people worldwide, typically causing chronic liver damage and severe complications such as liver failure. Currently, there are few approved treatments for viral infection. Thus, the HCV RNA-dependent RNA polymerase (gene product NS5B) has emerge...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3943204/ https://ncbi.nlm.nih.gov/pubmed/22855387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24154 |
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