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Allosteric Inhibitors Have Distinct Effects, but Also Common Modes of Action, in the HCV Polymerase
The RNA-dependent RNA polymerase from the Hepatitis C Virus (gene product NS5B) is a validated drug target because of its critical role in genome replication. There are at least four distinct allosteric sites on the polymerase to which several small molecule inhibitors bind. In addition, numerous cr...
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| Gepubliceerd in: | Biophys J |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The Biophysical Society
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4390812/ https://ncbi.nlm.nih.gov/pubmed/25863069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.03.005 |
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