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Atg7 overcomes senescence and promotes growth of BRAF(V600E)-driven melanoma
Macroautophagy (autophagy hereafter) may promote survival and growth of spontaneous tumors, including melanoma. We utilized a genetically engineered mouse model (GEMM) driven by oncogenic BRAF(V600E) and deficiency in the Pten tumor suppressor gene in melanocytes to test the functional consequences...
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| Publicado en: | Cancer Discov |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4390491/ https://ncbi.nlm.nih.gov/pubmed/25673642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1473 |
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