Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2a) activity and impairs cardiac function in mice

Sarcolipin (SLN) inhibits the cardiac sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2a) by direct binding and is superinhibitory if it binds through phospholamban (PLN). To determine whether overexpression of SLN in the heart might impair cardiac function, transgenic (TG) mice were generated with...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Asahi, Michio, Otsu, Kinya, Nakayama, Hiroyuki, Hikoso, Shungo, Takeda, Toshihiro, Gramolini, Anthony O., Trivieri, Maria G., Oudit, Gavin Y., Morita, Takashi, Kusakari, Yoichiro, Hirano, Shuta, Hongo, Kenichi, Hirotani, Shinichi, Yamaguchi, Osamu, Peterson, Alan, Backx, Peter H., Kurihara, Satoshi, Hori, Masatsugu, MacLennan, David H.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2004
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC438953/
https://ncbi.nlm.nih.gov/pubmed/15201433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402596101
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια