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Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2a) activity and impairs cardiac function in mice

Sarcolipin (SLN) inhibits the cardiac sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2a) by direct binding and is superinhibitory if it binds through phospholamban (PLN). To determine whether overexpression of SLN in the heart might impair cardiac function, transgenic (TG) mice were generated with...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Asahi, Michio, Otsu, Kinya, Nakayama, Hiroyuki, Hikoso, Shungo, Takeda, Toshihiro, Gramolini, Anthony O., Trivieri, Maria G., Oudit, Gavin Y., Morita, Takashi, Kusakari, Yoichiro, Hirano, Shuta, Hongo, Kenichi, Hirotani, Shinichi, Yamaguchi, Osamu, Peterson, Alan, Backx, Peter H., Kurihara, Satoshi, Hori, Masatsugu, MacLennan, David H.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC438953/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15201433/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402596101
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