Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2a) activity and impairs cardiac function in mice

Sarcolipin (SLN) inhibits the cardiac sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2a) by direct binding and is superinhibitory if it binds through phospholamban (PLN). To determine whether overexpression of SLN in the heart might impair cardiac function, transgenic (TG) mice were generated with...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Asahi, Michio, Otsu, Kinya, Nakayama, Hiroyuki, Hikoso, Shungo, Takeda, Toshihiro, Gramolini, Anthony O., Trivieri, Maria G., Oudit, Gavin Y., Morita, Takashi, Kusakari, Yoichiro, Hirano, Shuta, Hongo, Kenichi, Hirotani, Shinichi, Yamaguchi, Osamu, Peterson, Alan, Backx, Peter H., Kurihara, Satoshi, Hori, Masatsugu, MacLennan, David H.
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 2004
Fag:	Biological Sciences
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC438953/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15201433/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402596101
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