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Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2a) activity and impairs cardiac function in mice

Sarcolipin (SLN) inhibits the cardiac sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2a) by direct binding and is superinhibitory if it binds through phospholamban (PLN). To determine whether overexpression of SLN in the heart might impair cardiac function, transgenic (TG) mice were generated with...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Asahi, Michio, Otsu, Kinya, Nakayama, Hiroyuki, Hikoso, Shungo, Takeda, Toshihiro, Gramolini, Anthony O., Trivieri, Maria G., Oudit, Gavin Y., Morita, Takashi, Kusakari, Yoichiro, Hirano, Shuta, Hongo, Kenichi, Hirotani, Shinichi, Yamaguchi, Osamu, Peterson, Alan, Backx, Peter H., Kurihara, Satoshi, Hori, Masatsugu, MacLennan, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC438953/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15201433/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402596101
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