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Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase
Radical S-adenosylmethionine (SAM) enzymes use a [4Fe-4S] cluster to generate a 5′-deoxyadenosyl radical. Canonical radical SAM enzymes are characterized by a β-barrel-like fold and SAM anchors to the differentiated iron of the cluster, which is located near the amino terminus and within the β-barre...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Pub. Group
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4389238/ https://ncbi.nlm.nih.gov/pubmed/25813242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7480 |
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