Anaerobic 5-Hydroxylbenzimidazole formation from aminoimidazole ribotide: an unanticipated intersection of thiamin and vitamin B(12) biosynthesis

Comparative genomics of the bacterial thiamin pyrimidine synthase (thiC) revealed a paralog of thiC (bzaF) clustered with anaerobic vitamin B(12) biosynthetic genes. Here we demonstrate that BzaF is a radical S-adenosylmethionine enzyme that catalyzes the remarkable conversion of aminoimidazole ribo...

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Foilsithe in:J Am Chem Soc
Main Authors: Mehta, Angad P., Abdelwahed, Sameh H., Fenwick, Michael K., Hazra, Amrita B., Taga, Michiko E., Zhang, Yang, Ealick, Steven E., Begley, Tadhg P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753784/
https://ncbi.nlm.nih.gov/pubmed/26237670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b03576
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