Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily

4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synthase catalyzes a complex rearrangement of 5-aminoimidazole ribonucleotide (AIR) to form HMP-P, the pyrimidine moiety of thiamin phosphate. The three-dimensional structures of HMP-P synthase and its complexes with the product HMP-P and...

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Detalhes bibliográficos
Main Authors: Chatterjee, Abhishek, Li, Simon, Zhang, Yang, Grove, Tyler L., Lee, Michael, Krebs, Carsten, Booker, Squire J., Begley, Tadhg P., Ealick, Steven E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587053/
https://ncbi.nlm.nih.gov/pubmed/18953358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.121
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