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Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily
4-Amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synthase catalyzes a complex rearrangement of 5-aminoimidazole ribonucleotide (AIR) to form HMP-P, the pyrimidine moiety of thiamin phosphate. The three-dimensional structures of HMP-P synthase and its complexes with the product HMP-P and...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587053/ https://ncbi.nlm.nih.gov/pubmed/18953358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.121 |
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