Elucidating Molecular Phenotypes Caused by the SORL1 Alzheimer’s Disease Genetic Risk Factor Using Human Induced Pluripotent Stem Cells

Predisposition to sporadic Alzheimer’s disease (SAD) involves interactions between a person’s unique combination of genetic variants and the environment. The molecular effect of these variants may be subtle and difficult to analyze with standard in vitro or in vivo models. Here we used hIPSCs to exa...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Young, Jessica E., Boulanger-Weill, Jonathan, Williams, Daniel A., Woodruff, Grace, Buen, Floyd, Revilla, Arra C., Herrera, Cheryl, Israel, Mason A., Yuan, Shauna H., Edland, Steven D., Goldstein, Lawrence S.B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388804/
https://ncbi.nlm.nih.gov/pubmed/25772071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.02.004
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