Effect of Potent γ-Secretase Modulator in Human Neurons Derived From Multiple Presenilin 1–Induced Pluripotent Stem Cell Mutant Carriers

IMPORTANCE: Although considerable effort has been expended developing drug candidates for Alzheimer disease, none have yet succeeded owing to the lack of efficacy or to safety concerns. One potential shortcoming of current approaches to Alzheimer disease drug discovery and development is that they r...

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Detalhes bibliográficos
Publicado no:JAMA Neurol
Main Authors: Liu, Qing, Waltz, Shannon, Woodruff, Grace, Ouyang, Joe, Israel, Mason A., Herrera, Cheryl, Sarsoza, Floyd, Tanzi, Rudolph E., Koo, Edward H., Ringman, John M., Goldstein, Lawrence S. B., Wagner, Steven L., Yuan, Shauna H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374637/
https://ncbi.nlm.nih.gov/pubmed/25285942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2014.2482
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