Cellular Size as a Means of Tracking mTOR Activity and Cell Fate of CD4+ T Cells upon Antigen Recognition

mTOR is a central integrator of metabolic and immunological stimuli, dictating immune cell activation, proliferation and differentiation. In this study, we demonstrate that within a clonal population of activated T cells, there exist both mTOR(hi) and mTOR(lo) cells exhibiting highly divergent metab...

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Bibliographic Details
Published in:PLoS One
Main Authors: Pollizzi, Kristen N., Waickman, Adam T., Patel, Chirag H., Sun, Im Hong, Powell, Jonathan D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388710/
https://ncbi.nlm.nih.gov/pubmed/25849206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121710
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