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mTOR, metabolism, and the regulation of T-cell differentiation and function

Upon antigen recognition, naive T cells undergo rapid expansion and activation. The energy requirements for this expansion are formidable, and T-cell activation is accompanied by dramatic changes in cellular metabolism. Furthermore, the outcome of antigen engagement is guided by multiple cues derive...

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Bibliographic Details
Main Authors: Waickman, Adam T, Powell, Jonathan D.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419491/
https://ncbi.nlm.nih.gov/pubmed/22889214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-065X.2012.01152.x
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