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Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells
AIM: To study the function and mechanism of bigelovin, a sesquiterpene lactone from the flower of Chinese herb Inula hupehensis, in regulating JAK2/STAT3 signaling and cancer cell growth. METHODS: HepG2 cells stably transfected with the STAT3-responsive firefly luciferase reporter plasmid (HepG2/STA...
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| Publicado no: | Acta Pharmacol Sin |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4387296/ https://ncbi.nlm.nih.gov/pubmed/25619393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.143 |
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