Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells

AIM: To study the function and mechanism of bigelovin, a sesquiterpene lactone from the flower of Chinese herb Inula hupehensis, in regulating JAK2/STAT3 signaling and cancer cell growth. METHODS: HepG2 cells stably transfected with the STAT3-responsive firefly luciferase reporter plasmid (HepG2/STA...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Acta Pharmacol Sin
Huvudupphovsmän: Zhang, Hao-hao, Kuang, Shan, Wang, Ying, Sun, Xiao-xiao, Gu, Yuan, Hu, Li-hong, Yu, Qiang
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2015
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387296/
https://ncbi.nlm.nih.gov/pubmed/25619393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.143
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk