Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway

Abnormalities in the JAK2/STAT3 pathway are involved in the pathogenesis of colorectal cancer (CRC), including apoptosis. However, the exact mechanism by which dysregulated JAK2/STAT3 signalling contributes to the apoptosis has not been clarified. To investigate the role of both JAK2 and STAT3 in th...

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Hlavní autoři: Du, Wan, Hong, Jie, Wang, Ying-Chao, Zhang, Yan-Jie, Wang, Ping, Su, Wen-Yu, Lin, Yan-Wei, Lu, Rong, Zou, Wei-Ping, Xiong, Hua, Fang, Jing-Yuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2012
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822699/
https://ncbi.nlm.nih.gov/pubmed/22050790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2011.01483.x
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