Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells

AIM: To study the function and mechanism of bigelovin, a sesquiterpene lactone from the flower of Chinese herb Inula hupehensis, in regulating JAK2/STAT3 signaling and cancer cell growth. METHODS: HepG2 cells stably transfected with the STAT3-responsive firefly luciferase reporter plasmid (HepG2/STA...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Acta Pharmacol Sin
Egile Nagusiak: Zhang, Hao-hao, Kuang, Shan, Wang, Ying, Sun, Xiao-xiao, Gu, Yuan, Hu, Li-hong, Yu, Qiang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387296/
https://ncbi.nlm.nih.gov/pubmed/25619393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.143
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