Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm

Activation-induced deaminase (AID) initiates mutagenic pathways to diversify the antibody genes during immune responses. The access of AID to the nucleus is limited by CRM1-mediated nuclear export and by an uncharacterized mechanism of cytoplasmic retention. Here, we define a conformational motif in...

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Detaylı Bibliyografya
Yayımlandı:J Exp Med
Asıl Yazarlar: Methot, Stephen P., Litzler, Ludivine C., Trajtenberg, Felipe, Zahn, Astrid, Robert, Francis, Pelletier, Jerry, Buschiazzo, Alejandro, Magor, Brad G., Di Noia, Javier M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387293/
https://ncbi.nlm.nih.gov/pubmed/25824822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141157
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