Epithelial Xbp1 Is Required for Cellular Proliferation and Differentiation during Mammary Gland Development

Xbp1, a key mediator of the unfolded protein response (UPR), is activated by IRE1α-mediated splicing, which results in a frameshift to encode a protein with transcriptional activity. However, the direct function of Xbp1 in epithelial cells during mammary gland development is unknown. Here we report...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Hasegawa, Daisuke, Calvo, Veronica, Avivar-Valderas, Alvaro, Lade, Abigale, Chou, Hsin-I, Lee, Youngmin A., Farias, Eduardo F., Aguirre-Ghiso, Julio A., Friedman, Scott L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387219/
https://ncbi.nlm.nih.gov/pubmed/25713103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00136-15
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