p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis

The stress-activated protein kinase (SAPK) p38 can induce apoptosis, and its inhibition facilitates mammary tumorigenesis. We found that during mammary acinar morphogenesis in MCF-10A cells grown in three-dimensional culture, detachment of luminal cells from the basement membrane stimulated mitogen-...

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Bibliographic Details
Main Authors: Wen, Huei-Chi, Avivar-Valderas, Alvaro, Sosa, Maria Soledad, Girnius, Nomeda, Farias, Eduardo F., Davis, Roger J., Aguirre-Ghiso, Julio A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229273/
https://ncbi.nlm.nih.gov/pubmed/21610252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001684
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