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p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis
The stress-activated protein kinase (SAPK) p38 can induce apoptosis, and its inhibition facilitates mammary tumorigenesis. We found that during mammary acinar morphogenesis in MCF-10A cells grown in three-dimensional culture, detachment of luminal cells from the basement membrane stimulated mitogen-...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3229273/ https://ncbi.nlm.nih.gov/pubmed/21610252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001684 |
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